Our laboratory uses a number of approaches to study learning and memory at multiple levels of analyses. Essentially, we use the best possible techniques we can to address the problems we are studying.
Although many of our studies include mice with defined mutations, we have also taken advantage of a number of other strategies to alter molecular function in the brain, including pharmacology and gene manipulations with viral vectors.
We are using time-lapse two-photon imaging in vivo, our own head-mounted fluorescent microscopes in freely moving mice (2018 method of the year!, and optogenetics to define the cellular neurosystems involved in memory. We also use a number of electrophysiological approaches to study the cell biology of learning and memory. With head-mounted fluorescent microscopes we engineered in the lab, we are carrying out in vivo imaging of hippocampal and cortical circuits in freely behaving mice! These head-mounted fluorescent microscopes are giving us unprecedented access to the workings of neurocircuits in freely behaving mice!
Most of our studies start with extensive behavioral analyses. For this purpose our laboratory uses a number of tests that allow us to evaluate a wide range of rodent behaviors. We are also engaged in collaborative cognitive neuroscience studies of patients using techniques such as brain imaging
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