Cortical memories

<body topmargin=0 leftmargin=0 marginheight=0 marginwidth=0> <table cellpadding=0 cellspacing=0 border=0 height="100%"><tr> <td valign="top" width=12.5% BGCOLOR="#FFFFFF" TEXT="#080000"> <bR> </td> <td valign="top" width="100%" style=" border-top: 26px solid #FFFFFF; border-left: 63px solid #FFFFFF;border-right: 63px solid #FFFFFF;" BGCOLOR="#FFFFFF" TEXT="#080000"> <div> <TABLE BORDER="1" CELLPADDING="0" CELLSPACING="0" WIDTH="885" BORDERCOLORLIGHT="#808080" BORDERCOLORDARK="#FFFFFF" FRAME="BOX" RULES="ALL" HSPACE="0" VSPACE="0" > <tR> <tD VALIGN=TOP BGCOLOR=#DDDDDD HEIGHT= 88 ><NOBR><div> <B><IMG SRC="14d61e4a0.png" border=0 width="798" height="74" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"><IMG SRC="152953530.jpg" border=0 width="83" height="83" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></B></div> </NOBR></tD> </tR> <tR> <tD VALIGN=TOP BGCOLOR=#BBBBBB HEIGHT= 30 ><NOBR><div> <A HREF="index.htm" TARGET="_top" TITLE="Silvalab"><B> <IMG SRC="154761190.png" border=0 width="97" height="25" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></B></A><B> </B><A HREF="projects.htm" TARGET="_top" TITLE="Projects "><B><IMG SRC="147e61190.png" border=0 width="97" height="25" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></B></A><A HREF="approaches.htm" TARGET="_top" TITLE="Approaches"><B><IMG SRC="147f61190.png" border=0 width="97" height="25" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></B></A><A HREF="publications.htm" TARGET="_top" TITLE="Publications"><B><IMG SRC="148061190.png" border=0 width="97" height="25" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></B></A><A HREF="personnel.htm" TARGET="_top" TITLE="Lab Members"><B><IMG SRC="148161190.png" border=0 width="97" height="25" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></B></A><A HREF="alcino.htm" TARGET="_top" TITLE="Alcino J. Silva"><B><IMG SRC="148261190.png" border=0 width="97" height="25" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></B></A><A HREF="awards.htm" TARGET="_top" TITLE="Awards"><B><IMG SRC="148361190.png" border=0 width="97" height="25" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></B></A><A HREF="positions.htm" TARGET="_top" TITLE="Open Positions"><B><IMG SRC="148461190.png" border=0 width="97" height="25" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></B></A><A HREF="aboutus.htm" TARGET="_top" TITLE="aboutus"><B><IMG SRC="148561190.png" border=0 width="97" height="25" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></B></A></div> </NOBR></tD> </tR> <tR> <tD VALIGN=TOP BGCOLOR=#6666CC HEIGHT= 20 WIDTH="881"><IMG BORDER="0" SRC="1x1.gif" HEIGHT="20" ALIGN="bottom" WIDTH="881" HSPACE="0" VSPACE="0"></tD> </tR> </TABLE></div> <bR> <div> <TABLE BORDER="1" CELLPADDING="4" CELLSPACING="0" WIDTH="883" BORDERCOLORLIGHT="#330000" BORDERCOLORDARK="#FFFFFF" FRAME="BOX" RULES="ALL" HSPACE="0" VSPACE="0" BGCOLOR=#EEEEEE > <tR> <tD VALIGN=TOP BGCOLOR=#FFFFFF HEIGHT= 420 WIDTH="235"><div> Projects:</div> <bR> <div> <A HREF="aging.htm" TARGET="_top" TITLE="Aging and Cognition"><B>Aging and Cognition</B></A></div> <div> <A HREF="camkii.htm" TARGET="_top" TITLE="CaMKII and learning"><B>CaMKII and learning</B></A></div> <div> <A HREF="enhancements.htm" TARGET="_top" TITLE="Cognitive enhancements"><B>Cognitive enhancements</B></A></div> <div> <B><IMG BORDER="0" SRC="Symb075c00b700f000000000.png" HEIGHT="16" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Cortical memories</B></div> <div> <A HREF="recovery.htm" TARGET="_top" TITLE="Enhancing plasticity and recovery"><B>Enhancing plasticity and recovery</B></A></div> <div> <A HREF="disabilities.htm" TARGET="_top" TITLE="Learning disabilities"><B>Learning disabilities</B></A></div> <div> <A HREF="allocation.htm" TARGET="_top" TITLE="Memory allocation"><B>Memory allocation</B></A></div> <div> <A HREF="genes.htm" TARGET="_top" TITLE="Novel memory genes"><B>Novel memory genes</B></A></div> <div> <A HREF="schizophrenia.htm" TARGET="_top" TITLE="Schizophrenia"><B>Schizophrenia</B></A></div> <div> <A HREF="s2.htm" TARGET="_top" TITLE="Science of Science"><B>Science of Science</B></A></div> <bR> <div>    <A HREF="approaches339.htm" TARGET="_top" TITLE="in vivo Imaging">Our 2-photon experiments</A></div> <div> <B>    </B><A HREF="approaches339.htm" TARGET="_top" TITLE="in vivo Imaging"><B><IMG SRC="154177590.jpg" border=0 width="119" height="89" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></B></A></div> </tD> <tD VALIGN=TOP BGCOLOR=#FFFFFF WIDTH="626"><div> <IMG SRC="1531dba90.jpg" border=0 width="219" height="169" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></div> <bR> <div> Cortical plasticity and remote memory</div> <bR> <div> Our laboratory has started a new project focused on unraveling the molecular, cellular and systems mechanisms responsible for remote memory storage in neocortcal networks. Although there is very little known about how our oldest memories are stored, our laboratory has already demonstrated the involvement of specific molecular processes and physiological mechanisms in this fascinating phase of memory. </div> <bR> <bR> </tD> </tR> <tR> <tD VALIGN=TOP COLSPAN=2 BGCOLOR=#FFFFFF HEIGHT= 140 WIDTH="863"><div> Conte Center for Plasticity and Memory</div> <bR> <div> We have a long standing collaboration with the laboratories of Joshua Trachetenberg, Kevin Fox, and Michael Stryker on molecular and cellular mechanisms involved in cortical pasticity. Our results suggest that these mechanisms have a central role in remote memory. These studies are continuing under the auspices of our new <A HREF="cpm.htm" TARGET="_top" TITLE="CPM">NIMH Conte Center.</A></div> </tD> </tR> <tR> <tD VALIGN=TOP COLSPAN=2 BGCOLOR=#FFFFFF HEIGHT= 504 WIDTH="863"><div> Key references</div> <bR> <div> Matynia, A., S.G. Anagnostaras, B.J. Wiltgen, M. Lacuesta, M.S. Fanselow, and A.J. Silva, A high through-put reverse genetic screen identifies two genes involved in remote memory in mice. PLoS ONE, 2008. 3(5): p. e2121.(<A HREF="http://www.silvalab.com.cnchost.com/silvapapers/Annaplos2008.pdf" TARGET="_top" TITLE="http://www.silvalab.com.cnchost.com/silv">Click Here</A>)</div> <bR> <div> Wiltgen, BJ. Silva, AJ. Memory for context becomes less specific with time Learning and Memory, 2007, 14: 313-317 (<A HREF="http://www.silvalab.com.cnchost.com/silvapapers/BrianLM2007.pdf" TARGET="_top" TITLE="http://www.silvalab.com.cnchost.com/silv">PDF</A>).</div> <bR> <div> Frankland, P.W., Y. Wang, B. Rosner, T. Shimizu, B.W. Balleine, E.M. Dykens, E.M. Ornitz, and A.J. Silva, Sensorimotor gating abnormalities in young males with Fragile X syndrome and Fmr1-knockout mice. Molecular Psychiatry, 2004, 9, 417-425.(<A HREF="http://www.silvalab.com.cnchost.com/silvapapers/PaulMolPsy2004.pdf" TARGET="_top" TITLE="http://www.silvalab.com.cnchost.com/silv">PDF)</A></div> <bR> <div> Anagnostaras, S.G., G.G. Murphy, S.E. Hamilton, S.L. Mitchell, N.P. Rahnama, N.M. Nathanson, and A.J. Silva, Selective cognitive dysfunction in acetylcholine M(1) muscarinic receptor mutant mice. Nat Neurosci, 2003. 6(1): p. 51-58 (<A HREF="http://www.silvalab.com.cnchost.com/silvapapers/AnagnostarasNN.pdf" TARGET="_top" TITLE="http://www.silvalab.com.cnchost.com/silv">PDF)</A></div> <bR> <div> Frankland, P., C. O'Brien, M. Ohno, A. Kirkwood, and A. Silva, CaMKII-Dependent Plasticity in the neocortex is required for remote memory. Nature, 2001. 411: p. 309-13.<A HREF="http://www.silvalab.com.cnchost.com/paul'spaper.pdf" TARGET="_top" TITLE="http://www.silvalab.com.cnchost.com/paul">(PDF)</A></div> <bR> <div> Glazewski, S., K. Giese, A. Silva, and K. Fox, The role of alpha- CaMKII autophosphorylation in neocortical experience-dependent plasticity. Nature Neuroscience, 2000. 3: p. 911-918.</div> <bR> <div> Kirkwood, A., A. Silva, and M.F. Bear, Age-dependent decrease of synaptic plasticity in the neocortex of alphaCaMKII mutant mice. Proc Natl Acad Sci U S A, 1997. 94(7): p. 3380-3.<A HREF="http://www.silvalab.com.cnchost.com/Kirkwood-pnas.pdf" TARGET="_top" TITLE="http://www.silvalab.com.cnchost.com/Kirk">(PDF)</A></div> <bR> <div> Glazewski, S., C.M. Chen, A. Silva, and K. Fox, Requirement for alpha-CaMKII in experience-dependent plasticity of the barrel cortex. Science, 1996. 272(5260): p. 421-3.</div> <bR> <div> Gordon, J.A., D. Cioffi, A.J. Silva, and M.P. Stryker, Deficient plasticity in the primary visual cortex of alpha-calcium/calmodulin-dependent protein kinase II mutant mice. Neuron, 1996. 17(3): p. 491-9.</div> <bR> </tD> </tR> <tR> <tD VALIGN=TOP COLSPAN=2 BGCOLOR=#FFFFFF HEIGHT= 92 WIDTH="863"><bR> <bR> <div> <A HREF="projects.htm" TARGET="_top" TITLE="Projects ">Projects </A>   ·   <A HREF="approaches.htm" TARGET="_top" TITLE="Approaches">Approaches</A>   ·   <A HREF="publications.htm" TARGET="_top" TITLE="Publications">Publications</A>   ·   <A HREF="personnel.htm" TARGET="_top" TITLE="Lab Members">Lab Members</A>   ·   <A HREF="alcino.htm" TARGET="_top" TITLE="Alcino J. Silva">Alcino J. 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